Long-term protection from SARS coronavirus infection conferred by a single immunization with an attenuated VSV-based vaccine.
Identifieur interne : 004770 ( Main/Exploration ); précédent : 004769; suivant : 004771Long-term protection from SARS coronavirus infection conferred by a single immunization with an attenuated VSV-based vaccine.
Auteurs : Sagar U. Kapadia [États-Unis] ; John K. Rose ; Elaine Lamirande ; Leatrice Vogel ; Kanta Subbarao ; Anjeanette RobertsSource :
- Virology [ 0042-6822 ] ; 2005.
Descripteurs français
- KwdFr :
- Amorces ADN, Animaux, Cricetinae, Immunité cellulaire, Lignée cellulaire, Production d'anticorps, RT-PCR, Rein, Souris, Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux, Vaccins atténués, Vaccins à ADN, Virus de la stomatite vésiculeuse de type Indiana (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Virus de la stomatite vésiculeuse de type Indiana, Virus du SRAS.
- Amorces ADN, Animaux, Cricetinae, Immunité cellulaire, Lignée cellulaire, Production d'anticorps, RT-PCR, Rein, Souris, Vaccins antiviraux, Vaccins atténués, Vaccins à ADN.
English descriptors
- KwdEn :
- Animals, Antibody Formation, Cell Line, Cricetinae, DNA Primers, Immunity, Cellular, Kidney, Mice, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Vaccines, Attenuated, Vaccines, DNA, Vesicular stomatitis Indiana virus (immunology), Viral Vaccines.
- MESH :
- chemical : DNA Primers, Vaccines, Attenuated, Vaccines, DNA, Viral Vaccines.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, Vesicular stomatitis Indiana virus.
- Animals, Antibody Formation, Cell Line, Cricetinae, Immunity, Cellular, Kidney, Mice, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Although the recent SARS coronavirus (SARS-CoV) that appeared in 2002 has now been contained, the possibility of re-emergence of SARS-CoV remains. Due to the threat of re-emergence, the overall fatality rate of approximately 10%, and the rapid dispersion of the virus via international travel, viable vaccine candidates providing protection from SARS are clearly needed. We developed an attenuated VSV recombinant (VSV-S) expressing the SARS coronavirus (SARS-CoV) spike (S) protein. In cells infected with this recombinant, S protein was synthesized, glycosylated at approximately 17 Asn residues, and transported via the Golgi to the cell surface. Mice vaccinated with VSV-S developed SARS-neutralizing antibody and were able to control a challenge with SARS-CoV performed at 1 month or 4 months after a single vaccination. We also demonstrated, by passive antibody transfer, that the antibody response induced by the vaccine was sufficient for controlling SARS-CoV infection. A VSV-vectored SARS vaccine could have significant advantages over other SARS vaccine candidates described to date.
DOI: 10.1016/j.virol.2005.06.016
PubMed: 16043204
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Although the recent SARS coronavirus (SARS-CoV) that appeared in 2002 has now been contained, the possibility of re-emergence of SARS-CoV remains. Due to the threat of re-emergence, the overall fatality rate of approximately 10%, and the rapid dispersion of the virus via international travel, viable vaccine candidates providing protection from SARS are clearly needed. We developed an attenuated VSV recombinant (VSV-S) expressing the SARS coronavirus (SARS-CoV) spike (S) protein. In cells infected with this recombinant, S protein was synthesized, glycosylated at approximately 17 Asn residues, and transported via the Golgi to the cell surface. Mice vaccinated with VSV-S developed SARS-neutralizing antibody and were able to control a challenge with SARS-CoV performed at 1 month or 4 months after a single vaccination. We also demonstrated, by passive antibody transfer, that the antibody response induced by the vaccine was sufficient for controlling SARS-CoV infection. A VSV-vectored SARS vaccine could have significant advantages over other SARS vaccine candidates described to date.</div>
</front>
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